MARC details
| 000 -LEADER |
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| fixed length control field |
04933cam a2200445 i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
200454102 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
TR-AnTOB |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20241115090248.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS |
|---|
| fixed length control field |
m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr cnuaaaau |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
201001s2021 nju ob 001 0 eng |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781119524649 |
| Qualifying information |
(paperback) |
|
|---|
| Canceled/invalid ISBN |
9781119524656 |
| Qualifying information |
(e-book) |
|
|---|
| Canceled/invalid ISBN |
9781119524670 |
| Qualifying information |
(epub) |
|
|---|
| Canceled/invalid ISBN |
9781119524687 |
| Qualifying information |
(o-book) |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
DNLM/DLC |
| Language of cataloging |
eng |
| Description conventions |
rda |
| Transcribing agency |
DLC |
| Modifying agency |
TR-AnTOB |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
İngilizce |
| 060 00 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
W 20.55.C5 |
| Item number |
M149 2021 |
| 096 ## - LOCALLY ASSIGNED NLM-TYPE CALL NUMBER (OCLC) |
|---|
| Classification number |
W20.55.C5 |
| Item number |
M149 2021 EBK |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Machin, David |
| Relator term |
author |
| 9 (RLIN) |
143144 |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Randomised clinical trials : |
| Remainder of title |
design, practice and reporting / |
| Statement of responsibility, etc. |
David Machin, Peter M. Fayers, Bee Choo Tai. |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
Second edition |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
New Jersey : |
| Name of producer, publisher, distributor, manufacturer |
Wiley-Blackwell, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2021. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 online resource. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 500 ## - GENERAL NOTE |
|---|
| General note |
İncludes index. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Design Features -- The Trial Protocol -- Measurement and Data Capture -- Randomisation -- Trial Initiation -- Trial Conduct and Completion -- Basics for Analysis -- Trial Size -- Data and Safety Monitoring -- Reporting -- More than Two Interventions -- Paired and Matched Designs -- Repeated Measures Design -- Non-Inferiority and Equivalence Trials -- Cluster Designs -- Stepped Wedge Designs -- Genomic Targets -- Feasibility and Pilot Studies -- Further Topics. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
"It is now more than ten years since the first edition of this book was published. In the intervening years, while many things have remained unchanged, there have also been many new developments over the period. This second edition refreshes the first, refining some of the sections to better explain their contents and, at the same time, replacing some examples with more current illustrations. To reflect the changes, we have created new chapters by splitting and then expanding old chapters. Thus, we now include full chapters on data and safety monitoring including interim analyses of accumulating data, cluster designs, repeated measures, and non-inferiority designs as there has been a rapid increase in the use of such trial designs along with some methodological developments and improvements in statistical software available for analysis. In addition, we have included entirely new chapters on stepped wedge designs, genomic targets and, feasibility and pilot studies. The chapter on stepped wedge designs reflects the growing importance of such complex intervention designs while that on genomic targets highlights the research focus directed towards more individualised medicine. In contrast the new chapter concerned with feasibility and pilot studies brings us back to the early planning stages of the clinical trial which is planned. The chapter is included as there is increasing recognition that perhaps a more structured approach is required at the planning stage of any proposed trial. The intention is to help avoid the conduct of clinical trials which fail due to the basic assumptions made at the planning stage being inappropriate. This edition is divided into three sections: I Basic Considerations, II Adaptions of the Basic Design, and III Further Topics. As the title suggests, the first section is intended to cover topics that are relevant to all randomised trials of whatever design and complexity. Thus, it may be the key section for those who are new to clinical trials and an aide-memoire for those more experienced in this area. For this purpose, it concentrates on the parallel two-group controlled trial with a single outcome measure where patients are randomised individually to one of the two interventions concerned. The second section expands on the individually randomised design in several ways by considering paired designs, repeated assessments of the (same) outcome measure over time, more than two interventions, and non-inferiority trials. It also includes cluster trials, and stepped wedge designs in which groups rather than individuals are randomised to the interventions concerned. The final section deals with genomic targets, feasibility and pilot studies, and a final chapter on miscellaneous topics including adaptive designs, large simple trials and very small trials with new additions describing alpha spending functions and the predictive probability test for use in interim analyses"-- |
| Assigning source |
Provided by publisher. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Randomized Controlled Trials as Topic |
| General subdivision |
methods |
| 9 (RLIN) |
143145 |
|
|---|
| Topical term or geographic name entry element |
Biomedical Research |
| General subdivision |
methods |
| 9 (RLIN) |
128330 |
|
|---|
| Topical term or geographic name entry element |
Research Design |
| 9 (RLIN) |
99434 |
| 655 #0 - INDEX TERM--GENRE/FORM |
|---|
| Genre/form data or focus term |
Electronic books |
| 9 (RLIN) |
2032 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fayers, Peter M. |
| Relator term |
author |
| 9 (RLIN) |
143146 |
|
|---|
| Personal name |
Tai, Bee Choo |
| Relator term |
author |
| 9 (RLIN) |
143147 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Public note |
Online access link to the resource |
| Uniform Resource Identifier |
<a href="https://onlinelibrary.wiley.com/doi/book/10.1002/9781119524687">https://onlinelibrary.wiley.com/doi/book/10.1002/9781119524687</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
National Library of Medicine |
| Koha item type |
E-Book |
