The peripheral T-cell lymphomas / edited by Owen A. O'Connor, Won Seog Kim, Pier Luigi Zinzani.

Includes bibliographical references and index.

Fundamentals T-Cell Lymphocyte Biology / Claudio Tripodo, Stefano Pilleri -- Mechanisms of T-Cell Lymphomagenesis / François Lemonnier, Philippe Gaulard, Laurence de Leval -- Epigenetics of T-Cell Lymphoma / H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen O'Connor, Sean Harrop -- Animal Models of T-Cell Lymphoma / Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe, Mamiko Sakata-Yanagimoto -- The Geographic Distribution of the PTCL : Global Epidemiology / Amulya Yellala, Avyakta Kallam, James Armitage -- Classification of the Peripheral T-Cell Lymphomas / Neval Ozkaya, Elaine Jaffee -- Molecular Classification of the PTCLs / Tyler A. Herek, Javed Iqbal -- Peripheral T-Cell Lymphoma -- Not Otherwise Specified / Nora Bennani, Stephen Ansell -- Angioimmunoblastic T-Cell Lymphoma (AITL) / Jehan Dupuis, Franck Morschhauser -- The Spectrum of Anaplastic Large Cell Lymphoma / Jianping Kong, Andrew Feldman -- HTLV-1-Positive Adult T-Cell Leukemia-Lymphoma (ATL) / Wataru Munakata, Kensei Tobinai -- Natural Killer/T Cell Lymphomas / S.J. Kim, R. Suzuki, A. Jaccard, S.T. Lim, Won Seog Kim -- T-Prolymphocytic Leukemia (T-PLL) / Dima El-Sharkawi, Claire Deardon -- Large Granular Lymphocytes Leukemia (LGL) / Karolina H. Dziewulska, Katharine B. Moosic, HeeJin Cheon, Kristine C. Olson, David J. Feith, Thomas P. Loughran, Jr

Gamma Delta T-Cell Lymphomas / Francine Foss, Aadil Ahmed, Mina Xu -- Enteropathy Associated T-Cell Lymphoma and Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma / Craig R. Soderquist, Jennifer Shingleton, Sandeep Dave, Govind Bhagat -- Hepatosplenic T-Cell Lymphomas / Robert N. Stuver, Mwanasha Merrill, Salvia Jain -- Cutaneous T-Cell Lymphoma / Alejandro Ariel Gru, Bethanie Rooke, Kevin Molloy, Julia Scarsbrick -- Other Rare Subtypes of PTCL / Pier Paolo Picaluga -- Standard Front-line Therapies / Raphael Koch, Lorenz Truemper -- Approved Agents in the Relapsed or Refractory Setting, Excluding Brentuximab Vedotin / Helen Ma, Owen A. O'Connor -- The Role for Autologous Stem Cell Transplantation (ASCT) in Peripheral T Cell Lymphomas (PTCL) / Juan Alejandro Ospina, H. Martinez-Cordero, J. Enciso, H. Idrobo -- Allogeneic Stem Cell Transplantion / Anna Dodero, Paolo Corradini -- Emerging Immunotherapy Approaches in Peripheral T-Cell Lymphomas / Barbara Pro, Andrei Shustov -- Emerging New Small Molecules in Peripheral T-Cell Lymphomas / Alessandro Broccoli, Pier Luigi Zinzani -- The Value and Relevance of T-Cell Lymphoma Registries / Tetiana Skrypets, Martina Manni, Monica Civallero, Iryna Kriachok, Massimo Federico -- Innovative Chemotherapy-Free Approaches for the Treatment of PTCL / Enrica Marchi, Ahmed Sawas, Helen Ma, Luigi Scotto, Francesca Montanari -- Global Collaborations / Dejan Radjeski, Eliza Hawke, Owen A. O'Connor, Pier Luigi Zinzani, WonSeog Kim, Enrica Marchi

"The immune system can be classified into 2 basic component: (1) the innate immune system, and (2) the acquired immune system. The innate immune system is considered to be relatively agnostic to any specific antigen, and is often described as invariant. The innate immune response is the first line of defense, and typically exhibits limited specificity. Examples of innate immune response may include phagocytosis by macrophases, barriers to infect provided by the skin and tears, NK- and mast cells, and complement mediated cytolysis. In contrast, the adaptive (or sometimes called acquired) immune response develops in response to specific antigen, being 'custom' designed for the antigen in question, usually occurs later in the immune response, and has the ability to recall the response to past infections. Components of a functioning acquired immune response might involve antigen presenting cells presenting antigen ot T-cells, the activation of specific T-cells which would signal to B-cells enlisting their engagement in the response and the production of highly specific antibody capable of binding specific antigen. T- and B- lymphocytes are the major types of lymphocytes found in the human body, where they can constitute 20-40% of all white blood cells, with only about 2-3% of these being found in the peripheral circulation, the remainder being localized to various lymphoid organ is (lymph nodes, spleen, submucosal tissue). Remarkably, the total mass of lymphocytes in the body can approximate the mass of the brain and liver"-- Provided by publisher