Clinical diagnosis and management by laboratory methods

The clinical laboratory -- General concepts and administrative issues -- Optimizing laboratory workflow and performance -- Pre-analysis -- Analysis: principles of instrumentation -- Analysis: clinical laboratory automation -- Point-of-care and physician office laboratories -- Post-analysis: medical decision-making -- Interpreting laboratory results -- Laboratory statistics -- Quality control -- Clinical laboratory informatics -- Financial management -- Biological, chemical and nuclear terrorism: role of the laboratory -- Clinical chemistry -- Evaluation of renal function, water, electrolytes and acid-base balance -- Biochemical markers of bone metabolism -- Carbohydrates -- Lipids and dyslipoproteinemia -- Cardiac injury, atherosclerosis, and thrombotic disease -- Specific proteins -- Clinical enzymology -- Evaluation of liver function -- Laboratory diagnosis of gastrointestinal and pancreatic disorders -- Toxicology and therapeutic drug monitoring -- Evaluation of endocrine function -- Reproductive function and pregnancy -- Vitamins and trace elements -- Chemical basis for analyte assays and common interferences -- Urine and other body fluids -- Basic examination of urine -- Cerebrospinal, synovial, and serous body fluids -- Hematology, coagulation, and transfusion medicine -- Basic examination of blood and bone marrow -- Hematopoiesis -- Erythrocytic disorders -- Leukocytic disorders -- The flow cytometric evaluation of hematopoietic neoplasia -- Immunohematology -- Transfusion medicine -- Hemapheresis -- Tissue banking and progenitor cells -- Hemostasis and thrombosis -- Coagulation and fibrinolysis -- Blood platelets and Von Willebrand Disease -- Laboratory approach to thrombotic risk -- Antithrombotic therapy.

Immunology and immunopathology -- Overview of the immune system and immunologic disorders -- Immunoassays and immunochemistry -- Laboratory evaluation of the cellular immune system -- Laboratory evaluation of immunoglobin function and humoral immunity -- Mediators of inflammation: complement, cytokines, and adhesion molecules -- Human leukocyte antigen: the major histocompatibility complex of man -- The major histocompatibility complex and disease -- Immunodeficiency disorders -- Clinical and laboratory evaluation of systemic rheumatic diseases -- Vasculitis -- Organ-specific autoimmune diseases -- Allergic diseases -- Medical microbiology -- Viral infections -- Chlamydial, rickettsial, and mycoplasmal infections -- Medical bacteriology -- In vitro testing of antimicrobial agents -- Spirochete infections -- Mycobacteria -- Mycotic diseases -- Medical parasitology -- Specimen collection and handling for diagnosis of infectious diseases -- Molecular pathology -- Introduction to molecular pathology -- Molecular diagnostics: basic principles and techniques -- Polymerase chain reaction and other chain reaction amplification technology -- Hybridization array technologies -- Applications of cytogenetics in modern pathology -- Establishing a molecular diagnostics laboratory -- Molecular diagnosis of genetic diseases -- Identity analysis: use of DNA polymorphisms in parentage and forensic testing -- Pharmacogenomics and personalized medicine -- Clinical pathology of cancer -- Diagnostic and management of cancer using serologic tumor markers -- Oncoproteins and early tumor detection -- Molecular diagnosis of hematopoietic neoplasms -- Molecular genetic pathology of solid tumors -- High-throughput genomic and proteomic technologies in the post-genomic era -- Physiologic solutions, buffers, acid-base indicators, standard reference materials, and temperature conversions -- Desirable weights, body surface area, and body mass index (BMI) -- Approximations of total blood volume (TBV) -- Periodic table of the elements -- SI units -- Common chimeric genes identified in human malignancies -- Disease/organ panels -- Guidelines for ordering blood for elective surgery.