000			03886nam a2200541 i 4500
999			_c200426630 _d44554
001			9780750313704
003			IOP
005			20230918111136.0
006			m eo d
007			cr cn |||m|||a
008			170209s2017 enka ob 000 0 eng d
020			_a9780750313704 _qebook
024	7		_a10.1088/978-0-7503-1370-4 _2doi
035			_a(CaBNVSL)thg00972302
035			_a(OCoLC)973893520
040			_aCaBNVSL _beng _erda _cCaBNVSL _dCaBNVSL
060		4	_aWN 250 _bP128p 2017eb
100	1		_aPaganetti, Harald, _eauthor.
245	1	0	_aProton beam therapy / _cHarald Paganetti.
264		1	_aBristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : _bIOP Publishing, _c[2017]
300			_a1 online resource (x, 23 pages) : _bcolor illustrations.
336			_atext _2rdacontent _btxt
337			_aelectronic _2isbdmedia _bn
338			_aonline resource _2rdacarrier _bnc
490	0		_aPhysics world discovery, _x2399-2891
500			_a"Version: 20170101"--Title page verso.
500			_aIOP science open access books
505	0		_aIntroduction -- Why proton beams? -- Technical challenges -- Physics challenges -- Biological challenges -- Clinical challenges -- Outlook.
520	3		_aCancer therapy is a multi-modality approach including surgery, systemic or targeted chemotherapy, radiation (external beam or radionuclide), and immunotherapy. Radiation is typically administered using external beam photon therapy. Proton therapy has been around for more than 60 years but was restricted to research laboratories until the 1990s. Since then clinical proton therapy has been growing rapidly with currently more than 50 facilities worldwide. The interest in proton therapy stems from the physical properties of protons allowing for advanced dose sculpting around the target and sparing of healthy tissue. This review first evaluates the basics of proton therapy physics and technology and then outlines some of the current physical, biological, and clinical challenges. Solving these will ultimately determine whether proton therapy will continue on its path to becoming mainstream.
521			_aFinal-year undergraduates, new PhD students and early-career scientists.
530			_aAlso available in print.
538			_aSystem requirements: Adobe Acrobat Reader, EPUB reader. or Kindle reader.
538			_aMode of access: World Wide Web.
545			_aProfessor Harald Paganetti PhD is the Director of Physics Research at the Department of Radiation Oncology at Massachusetts General Hospital and a Professor of Radiation Oncology at Harvard Medical School. He received his PhD in experimental nuclear physics in 1992 from the Rheinische-Friedrich-Wilhelms University in Bonn, Germany, and has been working in radiation therapy research on experimental as well as theoretical aspects since 1994. He has authored and co-authored more than 200 peer-reviewed publications and has edited two books on Proton Therapy. He has made significant contributions to the field of radiation oncology physics, many of which have found their way into clinical practice. Particularly, he is a pioneer in advanced Monte Carlo dose calculations for proton therapy treatment planning and is considered the world expert on the relative biological effectiveness of proton beams.
588			_aTitle from PDF title page (viewed on February 9, 2017).
650	1	2	_aHealth Physics.
650		0	_aCancer _xRadiotherapy.
650	1	2	_aProton Therapy.
650		7	_aPhysics. _2bisacsh
650	1	2	_aNeoplasms _xradiotherapy.
650		7	_aSCIENCE / Physics / Astrophysics. _2bicssc
650		0	_aMedical physics.
650		0	_aProton beams _xTherapeutic use.
710	2		_aInstitute of Physics (Great Britain), _epublisher.
856	4	0	_uhttp://iopscience.iop.org/book/978-0-7503-1370-4
942			_2NLM _cEBK