000 | 02923nam a22004935i 4500 | ||
---|---|---|---|
999 |
_c200434224 _d52436 |
||
003 | DE-He213 | ||
005 | 20231104114330.0 | ||
007 | cr nn 008mamaa | ||
008 | 150122s2015 gw | s |||| 0|eng d | ||
020 |
_a9783319149141 _z978-3-319-14914-1 |
||
024 | 7 |
_a10.1007/978-3-319-14914-1 _2doi |
|
040 |
_aTR-AnTOB _beng _cTR-AnTOB _erda |
||
050 | 4 | _aQH324.2-324.25 | |
072 | 7 |
_aPSA _2bicssc |
|
072 | 7 |
_aCOM014000 _2bisacsh |
|
072 | 7 |
_aPSA _2thema |
|
072 | 7 |
_aUB _2thema570.285 _223 |
|
100 | 1 |
_aXu, Jinbo. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut |
|
245 | 1 | 0 |
_aProtein Homology Detection Through Alignment of Markov Random Fields : _bUsing MRFalign / _cby Jinbo Xu, Sheng Wang, Jianzhu Ma. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2015. |
|
300 | _a1 online resource | ||
336 |
_atext _btxt _2rdacontent |
||
337 |
_acomputer _bc _2rdamedia |
||
338 |
_aonline resource _bcr _2rdacarrier |
||
347 |
_atext file _bPDF _2rda |
||
490 | 0 |
_aSpringerBriefs in Computer Science, _x2191-5768 |
|
505 | 0 | _aIntroduction -- Method -- Software -- Experiments and Results -- Conclusion. | |
520 | _aThis work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method. | ||
650 | 0 | _aBioinformatics. | |
650 | 0 | _aComputer science. | |
650 | 0 | _aStatistics. | |
650 | 1 | 4 |
_aComputational Biology/Bioinformatics. _0http://scigraph.springernature.com/things/product-market-codes/I23050 |
650 | 2 | 4 |
_aProbability and Statistics in Computer Science. _0http://scigraph.springernature.com/things/product-market-codes/I17036 |
650 | 2 | 4 |
_aBioinformatics. _0http://scigraph.springernature.com/things/product-market-codes/L15001 |
650 | 2 | 4 |
_aStatistics for Life Sciences, Medicine, Health Sciences. _0http://scigraph.springernature.com/things/product-market-codes/S17030 |
700 | 1 |
_aWang, Sheng. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut |
|
700 | 1 |
_aMa, Jianzhu. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut |
|
710 | 2 | _aSpringerLink (Online service) | |
856 | 4 | 0 |
_uhttps://doi.org/10.1007/978-3-319-14914-1 _3Springer eBooks _zOnline access link to the resource |
942 |
_2lcc _cEBK |
||
041 | _aeng |