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020 _a9789048122981
_c(v.4 : ebook)
020 _a9789048122974 (v. 4 : alk. paper)
024 7 _a10.1007/978-90-481-2298-1
040 _aDNLM
_beng
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_dTR-AnTOB
041 0 _aeng
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_bH23585 2009
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096 _aWM 140
_bH23585 2009EBK
245 1 4 _aThe handbook of neuropsychiatric biomarkers, endophenotypes, and genes :
_bvolume IV Molecular genetic and genomic markers /
_cedited by Michael S. Ritsner.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2009.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent.
337 _acomputer
_bc
_2rdamedia.
338 _aonline resource
_bcr
_2rdacarrier.
347 _atext file
_bPDF
_2rda.
505 0 _aMolecular Genetic and Genomic Markers -- Pharmacogenomic Biomarkers in Neuropsychiatry: The Path to Personalized Medicine in Mental Disorders -- Pharmacogenetics in Neurological Diseases -- Gene Expression Changes and Potential Impact of Endophenotypes in Major Psychiatric Disorders -- Molecular Genetics of Schizophrenia: Focus on Symptom Dimensions -- Genetics of Mood Disorders -- Endophenotype Strategy in Epilepsy Genetics -- Epilepsy, Biomarkers, and Genes -- Molecular and Imaging Genetic Markers in Panic Disorder -- The Genetics of Obsessive–Compulsive Disorder -- Development of Biomarkers for Alcoholism and Polysubstance Abuse -- Role of Members of the Nur (NR4A) Transcription Factors in Dopamine-Related Neurodegenerative and Neuropsychiatric Disorders -- Afterword.
520 _aNeuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
700 1 _aRitsner, Michael S.
_eeditor
_9128185
856 4 0 _uhttps://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=277279
_zOnline access link to the resource.
942 _2NLM
_cEBK