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001			200452142
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005			20241209134658.0
006			m o d
007			cr cnu||||||||
008			220221s2022 nju o ||| 0 eng d
020			_a1119652030
020			_a9781119652038
020			_a1119652049
020			_a9781119652045
020			_a1119652057
020			_a9781119652052
035			_a(OCoLC)1317369148
040			_aSFB _beng _erda _epn _cSFB _dDG1 _dTR-AnTOB
041	0		_aeng
060	0		_aQZ 210 _bSV968 2022
096			_aQZ210 _bSV968 2022EBK
100	1		_aHeim, Sverre. _0http://id.loc.gov/authorities/names/n85273121 _eauthor
245	1	0	_aAbnormal chromosomes : _bthe past, present, and future of cancer cytogenetics / _cSverre Heim, Felix Mitelman
264		1	_aNewark : _bJohn Wiley & Sons, Incorporated, _c2022.
264		4	_c©2022
300			_a1 online resource (211 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aBIBINDX
520			_a"Explore the past, present, and future of cancer cytogenetics In Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics -- the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics. The book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders. From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process? How was information of this nature put to good use in the clinical management of cancer patients? Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics offers readers: A thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed Comprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer. A detailed chronological resume of cancer cytogenetic discoveries during the century. In-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populations. A discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation. The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients"-- _cProvided by publisher
650		0	_aChromosome abnormalities. _0http://id.loc.gov/authorities/subjects/sh85025385
650	1	2	_aNeoplasms _xgenetics. _0https://id.nlm.nih.gov/mesh/D009369Q000235 _9119996
650	2	2	_aCytogenetics _xmethods. _0https://id.nlm.nih.gov/mesh/D003582Q000379
650	2	2	_aChromosome Aberrations. _0https://id.nlm.nih.gov/mesh/D002869
655		0	_aElectronic books _92032
700	1		_aMitelman, Felix. _0http://id.loc.gov/authorities/names/n85000491 _eauthor
856	4	0	_3Wiley Online Library _zConnect to resource _uhttps://onlinelibrary.wiley.com/doi/book/10.1002/9781119652038
942			_2NLM _cEBK
999			_c200452142 _d70354