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020 _a9781119819950
_q(electronic bk. : oBook)
020 _a1119819954
_q(electronic bk. : oBook)
024 7 _a10.1002/9781119819950
_2doi
035 _a(OCoLC)1379304089
040 _aDG1
_beng
_erda
_epn
_cDG1
_dTR-AnTOB
041 0 _aeng
060 _aQZ 266
_bP922
096 _aQZ 266
_bP922 2023 EBK
245 0 0 _aPrecision cancer therapies.
_nVolume 1,
_pTargeting oncogenic drivers and signaling pathways in lymphoid malignancies :
_bfrom concept to practice /
_cedited by Owen A. O'Connor, Stephen M. Ansell, John F. Seymour
246 3 0 _aTargeting oncogenic drivers and signaling pathways in lymphoid malignancies
264 1 _aHoboken, NJ :
_bWiley Blackwell,
_c2023
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
340 _2rdacc
_0http://rdaregistry.info/termList/RDAColourContent/1003
506 _aAvailable to OhioLINK libraries
520 _aTargeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients - hence the subtitle, From Concept to Practice. To aid in readers' comprehension, the first page of each chapter contains a box entitled 'Take Home Points'. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies; Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis; Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically; Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control; Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches
650 0 _aLymphomas
_0https://id.loc.gov/authorities/subjects/sh85079154
_xTreatment.
_0https://id.loc.gov/authorities/subjects/sh99005040
650 0 _aCellular signal transduction.
_0https://id.loc.gov/authorities/subjects/sh89002397
650 1 2 _aLymphoma
_xtherapy.
_0https://id.nlm.nih.gov/mesh/D008223Q000628
650 2 2 _aSignal Transduction.
_0https://id.nlm.nih.gov/mesh/D015398
650 2 2 _aMolecular Targeted Therapy.
_0https://id.nlm.nih.gov/mesh/D058990
650 2 2 _aTumor Microenvironment.
_0https://id.nlm.nih.gov/mesh/D059016
655 0 _aElectronic books
_92032
700 1 _aO'Connor, Owen A.,
_0https://id.loc.gov/authorities/names/n2020184152
_eeditor
700 1 _aAnsell, Stephen M.,
_0https://id.loc.gov/authorities/names/no2008027310
_eeditor
700 1 _aSeymour, John F.,
_0https://id.loc.gov/authorities/names/n89669647
_eeditor
710 2 _aOhio Library and Information Network.
_0https://id.loc.gov/authorities/names/no95058981
856 4 0 _3Wiley Online Library
_zConnect to resource
_uhttps://onlinelibrary.wiley.com/doi/book/10.1002/9781119819950
942 _2NLM
_cEBK