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024	7		_a10.1007/978-981-16-7897-4 _2doi
040			_aTR-AnTOB _beng _cTR-AnTOB _erda
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245	1	0	_aTherapeutic Proteins Against Human Diseases _h[electronic resource] / _cedited by Fahmida Khatoon Zahid Balouch.
250			_a1st ed. 2022.
264		1	_aSingapore : _bSpringer Nature Singapore : _bImprint: Springer, _c2022.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aProteins drug targeting and its therapeutics -- Interferons -- Epidermal growth factor (egf) in wound repair -- Therapeutic protein against autoimmune disorders: Intracellular and extracellular properties -- Prions as Therapeutic proteins and their Prospect as Drug Delivery Agent -- INTERLEUKIN - 2 -- Bioinformatics resources, tools, and strategies in designing therapeutic proteins -- Therapeutic proteins used in human pancreatic disease -- Therapeutic role of soybean-derived lunasin peptide in colon cancer treatment: A recent updates from literature -- Therapeutic peptides in skin and hair disorders. .
520			_aThis book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics. This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.
650		0	_aTherapeutics.
650		0	_aDiseases.
650		0	_aPharmacology.
650		0	_aClinical biochemistry.
650		0	_aProteins .
650	1	4	_aTherapeutics.
650	2	4	_aDiseases.
650	2	4	_aPharmacology.
650	2	4	_aMedical Biochemistry.
650	2	4	_aProtein Biochemistry.
653		0	_aProteins -- therapeutic use
653		0	_aProteins -- drug effects
700	1		_aZahid Balouch, Fahmida Khatoon. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
856	4	0	_uhttps://doi.org/10.1007/978-981-16-7897-4 _3Springer eBooks _zOnline access link to the resource
942			_2NLM _cEBK
041			_aeng