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020 _a9783031142918
024 7 _a10.1007/978-3-031-14291-8
_2doi
040 _aTR-AnTOB
_beng
_erda
_cTR-AnTOB
060 _aWL 200
072 7 _aMMP
_2bicssc
072 7 _aMED080000
_2bisacsh
072 7 _aMKS
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096 _aWL200EBK
245 1 0 _aRadiopharmaceuticals in the Management of Leptomeningeal Metastasis
_h[electronic resource] /
_cedited by Franklin C.L. Wong.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aHuman Leptomeningeal Metastasis (LM)- Epidemiology and Challenges -- State of Art of LM Radiographic Diagnosis – Anatomic and Functional Imaging -- State of Art of LM Therapies: Intrathecal and Systemic approaches -- Current Practice of Radiation Therapy of LM -- Radionuclides in the Diagnosis and Therapy in Neuro-Oncology -- Radionuclide LM Therapy - Published Clinical Trial Findings -- Intrathecal LM Dosimetry Models- Radionuclides in CSF Spaces -- Human Radiation Dosimetry from Imaging- Guidance for Therapy -- Radiographic Assessment for Monitoring of LM Treatment -- Clinical Assessment for Monitoring of LM Treatment -- Logistic and Regulatory Aspects of Locoregional Radionuclide Therapy -- Radionuclides in the Management of LM– Challenges and Opportunities.
520 _aThis book reviews the current clinical practice of leptomeningeal metastasis (LM) diagnosis and treatment, which is predominately by intrathecal chemotherapy and/or in combination with external beam radiotherapy. LM is a refractory lethal complication of many human malignancies when neoplastic cells grow in the meninges. The use of penetrating emissions from radionuclides has the advantages of visualizing cerebrospinal fluid (CSF) flow and ablating meninges at shallow depths and has been used to diagnose CSF flow anomalies and to treat LM. The scientific bases of using radionuclides inside human CSF and ablating LM will be discussed within the text, with results from established and completed clinical trials to explore optimal use of radionuclides to diagnose and treat LM. Many limitations of current practices of treating LM are also discussed, as well as potential avenues of overcoming these limitations. This book is an ideal guide for clinical researchers in the practice of treating leptomeningeal metastasis including radiologists, neurologists, oncologists and radiotherapists as well as their associates.
650 0 _aRadiology.
650 0 _aInternal medicine.
650 0 _aNeurology .
650 1 4 _aRadiology.
650 2 4 _aInternal Medicine.
650 2 4 _aNeurology.
653 0 _aMeningeal Neoplasms -- secondary
653 0 _aMeningeal Carcinomatosis -- radiotherapy
653 0 _aRadiopharmaceuticals -- therapeutic use
700 1 _aWong, Franklin C.L.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
856 4 0 _uhttps://doi.org/10.1007/978-3-031-14291-8
_3Springer eBooks
_zOnline access link to the resource
942 _2NLM
_cEBK
041 _aeng