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020 _a9783030946586
024 7 _a10.1007/978-3-030-94658-6
_2doi
040 _aTR-AnTOB
_beng
_erda
_cTR-AnTOB
060 _aQZ 269
072 7 _aMMP
_2bicssc
072 7 _aMED080000
_2bisacsh
072 7 _aMKS
_2thema
096 _aQZ269EBK
100 1 _aSchultheiss, Timothy.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aRadiation Myelopathy
_h[electronic resource] /
_cby Timothy Schultheiss.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aHistory -- Pathogenesis of radiation myelopathy -- Clinical radiation myelopathy -- Radiation myelopathy in stereotactic radiosurgery -- Experimental studies on fractionation effects -- Experimental studies on volume effects -- Other clinical and experimental studies -- Multispecies dose response model -- Treatment of myelopathy -- Medico-legal issues.
520 _aThis book covers every aspect of radiation myelopathy and considers the evidence from all species in which it has been studied. The historical and current understanding of the pathogenesis of this rare but devastating injury is first discussed. The evidence regarding the role of a variety of factors in radiation myelopathy is then reviewed. Readers will find detailed information on the impacts of total radiation dose, radiation volume, dose fractionation, hyper fractionation, age, anatomic level, comorbidities, radiation modifiers, other therapies, and retreatment of the spinal cord. Given the similarity of the pathogenesis of radiation myelopathy in humans and experimental animals, the potential for cross-species modelling of dose response is explored, with attention to relevant species differences. Treatment of the condition is also fully considered. New theories are presented regarding retreatment, small volume response, and the final step in white matter necrosis. The final chapter addresses the medicolegal issues elicited by radiation myelopathy, which is often the result of treatment error. Radiation Myelopathy will be of high value for radiation oncologists, radiation physicists, dosimetrists, biologists, neurologists, medical oncologists, and attorneys.
650 0 _aRadiology.
650 0 _aEnvironmental health.
650 0 _aInternal medicine.
650 0 _aBiophysics.
650 1 4 _aRadiology.
650 2 4 _aEnvironmental Health.
650 2 4 _aInternal Medicine.
650 2 4 _aBiophysics.
653 0 _aNeoplasms -- radiotherapy
653 0 _aSpinal Cord Diseases
653 0 _aAbnormalities, Radiation-Induced
710 2 _aSpringerLink (Online service)
856 4 0 _uhttps://doi.org/10.1007/978-3-030-94658-6
_3Springer eBooks
_zOnline access link to the resource
942 _2NLM
_cEBK
041 _aeng