000			04749nam a22005415i 4500
999			_c200457792 _d76004
003			TR-AnTOB
005			20231109085834.0
007			cr nn 008mamaa
008			211127s2022 sz | s |||| 0|eng d
020			_a9783030867058
024	7		_a10.1007/978-3-030-86705-8 _2doi
040			_aTR-AnTOB _beng _erda _cTR-AnTOB
041			_aeng
060			_aWC 506
072		7	_aMMKL _2bicssc
072		7	_aMED015000 _2bisacsh
072		7	_aMKPL _2thema
096			_aWC506EBK
100	1		_aCascella, Marco. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aFeatures and Management of Acute and Chronic Neuro-Covid _h[electronic resource] / _cby Marco Cascella, Elvio De Blasio.
250			_a1st ed. 2022.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2022.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Part I. Pathophysiology of COVID-19-associated neurotoxicity -- An update on preclinical findings -- Ongoing clinical investigations -- Perspectives -- Part II. Clinical manifestations of acute neurotoxicity -- Clinical features -- CNS complications -- PNS complications -- Diagnosis.-Management -- Perspectives -- Part III. Neurological and psychiatric sequelae in COVID-19 survivors.-Clinical features -- Neurological late complications -- psychological and psychiatric sequelae.-Diagnosis -- Tools -- The role of imaging -- Preventive strategies -- Social and economic impact.-Multidisciplinary management -- Perspectives.
520			_aThis book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also be affected by infectious damage and clinical manifestations including Guillain-Barré syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients.
650		0	_aCritical care medicine.
650		0	_aNeurology .
650		0	_aPsychiatry.
650		0	_aPublic health.
650	1	4	_aIntensive Care Medicine.
650	2	4	_aNeurology.
650	2	4	_aPsychiatry.
650	2	4	_aPublic Health.
653		0	_aCOVID-19 -- physiopathology
653		0	_aNeurotoxicology
700	1		_aDe Blasio, Elvio. _eauthor. _4aut _4http://id.loc.gov/vocabulary/relators/aut
710	2		_aSpringerLink (Online service)
856	4	0	_uhttps://doi.org/10.1007/978-3-030-86705-8 _3Springer eBooks _zOnline access link to the resource
942			_2NLM _cEBK