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020 _a9783030851477
024 7 _a10.1007/978-3-030-85147-7
_2doi
040 _aTR-AnTOB
_beng
_cTR-AnTOB
_erda
041 _aeng
060 0 0 _aWH 260
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072 7 _aMED038000
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245 1 0 _aClinical Management of Acute Lymphoblastic Leukemia
_h[electronic resource] :
_bFrom Bench to Bedside /
_cedited by Mark R. Litzow, Elizabeth A. Raetz.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aTRANSLATIONAL SCIENCE -- Molecular pathways and targets in B cell progenitor acute lymphoblastic leukemia -- Genetic Mechanisms in T-Cell Acute Lymphoblastic Leukemia -- Minimal Residual Disease in Acute Lymphoblastic Leukemia – Techniques and Application -- THERAPEUTICS -- Treatment of Pediatric B and T cell ALL -- Treatment of Adult B and T cell Acute Lymphoblastic Leukemia: An Overview of Current Treatments and Novel Advances -- Acute Lymphoblastic Leukemia in Infants: A distinctive, high risk subtype of childhood ALL -- Treatment of Elderly Patients with Acute Lymphoblastic Leukemia -- Treatment of Childhood Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia -- Treatment of adult Philadelphia chromosome positive ALL -- Treatment of Ph-like ALL -- Prophylaxis and treatment of central nervous system (CNS) ALL -- Late effects of therapy of acute lymphoblastic leukemia -- NEW AND EXISTING MODALITIES OF THERAPY -- Monoclonal Antibody Based Treatment and Other New Agents for B-Lineage ALL -- New Agents for the Treatment of T-Cell ALL -- The development and management of treatment with chimeric-antigen receptor T cell (CAR-T) -- Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia (ALL) -- Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
520 _aThis book provides a state-of-the-art overview of acute lymphoblastic leukemia (ALL). The first section of the book presents the translational science behind ALL, reviewing molecular pathways and targets in B- and T-cell ALL, as well as techniques and application of minimal residual disease testing. The second section spotlights ALL management strategies for patients across the spectrum, from infants to the elderly. The final section outlines current and new advances in ALL treatment, including new monoclonal antibodies and allogenic and autologous HSCT. Written by experts in the field, Clinical Management of Acute Lymphoblastic Leukemia: From Bench to Bedside is a valuable resource that will guide patient management, stimulate investigative efforts, and increase understanding of the biologic underpinnings of the disease.
650 0 _aInternal medicine.
650 1 4 _aInternal Medicine.
650 2 4 _aInternal Medicine.
653 0 _aPrecursor Cell Lymphoblastic Leukemia-Lymphoma -- therapy
653 0 _aPrecursor Cell Lymphoblastic Leukemia-Lymphoma -- genetics
653 0 _aCombined Modality Therapy -- methods
653 0 _aTreatment Outcome
700 1 _aLitzow, Mark R.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRaetz, Elizabeth A.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
856 4 0 _uhttps://doi.org/10.1007/978-3-030-85147-7
_3Springer eBooks
_zOnline access link to the resource
942 _2NLM
_cEBK