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020 _a9783030871048
024 7 _a10.1007/978-3-030-87104-8
_2doi
040 _aTR-AnTOB
_beng
_cTR-AnTOB
_erda
060 _aWF 140
072 7 _aMJL
_2bicssc
072 7 _aMED079000
_2bisacsh
072 7 _aMJL
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096 _aWF140EBK
245 1 4 _aThe Microbiome in Respiratory Disease
_h[electronic resource] :
_bPrinciples, Tools and Applications /
_cedited by Yvonne J. Huang, Stavros Garantziotis.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Humana,
_c2022.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aRespiratory Medicine,
_x2197-7380
505 0 _aSECTION I: Principles and Tools of Respiratory Microbiome Investigation -- Conceptual Framework and Hypothesis Testing -- Study Design and Sampling Considerations -- Laboratory Platforms to Study the Microbiome -- Analysis and Reporting of Microbiome Data -- SECTION II: Applications in the Study of Specific Diseases -- Chronic Rhinosinusitis /Allergic Rhinitis -- Bronchiolitis, Viral Infection and Pediatric Asthma Risk -- Asthma Pheotype -- Cystic Fibrosis -- Bronchiectasis (non-CF) -- COPD -- Idiopathic Pulmonary Fibrosis -- Lung Transplantation and Immune Suppression -- The Future: Knowledge gaps and priorities.
520 _aThis book comprehensively covers the microbiome in respiratory disease, from the initial research study to the disease-specific implications and related applications. Research on the respiratory microbiome is increasing in volume and scope. This reflects rapidly growing interest in the study of respiratory disease to understand how microbiota shape mechanisms of disease pathogenesis. The respiratory tract spans the nasal passages, sinus cavities, oropharynx, and the tracheobronchial tree of the lungs. In these compartments of the upper and lower respiratory tract, the microbiota have now been studied in the context of several chronic respiratory conditions. These include chronic sinusitis, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and pulmonary fibrosis, to name a few. The potential impact of ecological interactions (i.e., between microbes and between microbiota and host) within and across respiratory compartments is increasingly recognized. The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant. This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology. .
650 0 _aRespiratory organs—Diseases.
650 0 _aInternal medicine.
650 1 4 _aPneumology.
650 2 4 _aInternal Medicine.
653 0 _aRespiratory Tract Diseases
653 0 _aMicrobiology
700 1 _aHuang, Yvonne J.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGarantziotis, Stavros.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
830 0 _aRespiratory Medicine,
_x2197-7380
856 4 0 _uhttps://doi.org/10.1007/978-3-030-87104-8
_3Springer eBooks
_zOnline access link to the resource
942 _2NLM
_cEBK
041 _aeng