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020 _a9783030805463
024 7 _a10.1007/978-3-030-80546-3
_2doi
040 _aTR-AnTOB
_beng
_erda
_cTR-AnTOB
060 _aWJ 160
072 7 _aMJ
_2bicssc
072 7 _aMED045000
_2bisacsh
072 7 _aMJ
_2thema
096 _aWJ160EBK
245 1 0 _aNeoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers
_h[electronic resource] :
_bMultidisciplinary Management /
_cedited by Andrea Necchi, Philippe E. Spiess.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- State-of-the art and ongoing developments -- Clinical cases debate: neoadjuvant checkpoint inhibition vs standard chemotherapy -- Slideshow of tumor samples before and after checkpoint inhibition -- Ongoing trials and clinical trials endpoints debate: the role of pathological response as a surrogate of survival endpoints -- State-of-the-art and future role of molecular biomarkers for patient selection -- Background of immunotherapy trials in prostate cancer -- Clinical case debate: immunotherapy vs alternative therapies in the neoadjuvant and adjuvant setting of localized, high-risk prostate cancer -- Cytoreductive nephrectomy in the era of targeted therapy and immunotherapy -- Clinical cases debate: Neoadjuvant vs adjuvant immunotherapy in localized RCC -- Benchmark of surgical safety results -- What the scientific data tell us about predictive biomarkers of immunotherapy efficacy across the GU malignancies -- Clinical cases debate: biomarker-driven patient selection vs unselective perioperative strategies. .
520 _aThis book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.
650 0 _aInternal medicine.
650 1 4 _aInternal Medicine.
653 0 _aUrogenital Neoplasms -- therapy
653 0 _aUrogenital Neoplasms -- diagnosis
653 0 _aUrogenital Neoplasms -- genetics
700 1 _aNecchi, Andrea.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aSpiess, Philippe E.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
856 4 0 _uhttps://doi.org/10.1007/978-3-030-80546-3
_3Springer eBooks
_zOnline access link to the resource
942 _2NLM
_cEBK
041 _aeng