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008			220422s2022 sz | s |||| 0|eng d
020			_a9783030939908
024	7		_a10.1007/978-3-030-93990-8 _2doi
040			_aTR-AnTOB _beng _cTR-AnTOB _erda
060		4	_aWH 325
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072		7	_aMED038000 _2bisacsh
072		7	_aMJF _2thema
096			_aWH325EBK
245	1	0	_aAdvances in Hemophilia Treatment _h[electronic resource] : _bFrom Genetics to Joint Health / _cedited by E. Carlos Rodríguez-Merchán.
250			_a1st ed. 2022.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2022.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1. Pathophysiology of hemophilia -- 2. Genetics of Hemophilia A and B -- 3. Inhibitors in Hemophilia A -- 4. Immune Tolerance In Patients with Hemophilia A -- 5. Hemophilia A: New drugs -- 6. Inhibitors in Hemophilia B -- 7. Immune Tolerance Induction in Hemophilia B -- 8. Hemophilia B: New Drugs -- 9. Management of Hemophilia Carriers -- 10. Pharmacoeconomic Aspects in Hemophilia -- 11. Assessment of Joint Health and Outcome Measures in Hemophilia -- 12. Musculoskeletal Medicine in Hemophilia -- 13. Management of Acute Hemarthrosis in Hemophilia (Including Joint Aspiration) -- 14. Hemophilic Arthropathy: Radiosynovectomy -- 15. Hemophilic Arthropathy: Arthroscopic Joint Debridement -- 16. Hemophilic Arthropathy: Total Joint Arthroplasty -- 17. Hemophilic Arthropathy: Other Orthopedic Procedures -- 18. Gene Therapy in Hemophilia: Latest Advances -- 19.A Summary of the Recent Recommendations of the WFH.
520			_aThis book offers a comprehensive and state of the art overview of hemophilia management by reviewing all most recent advances and cutting edge information in this fast evolving field. As hemophilia patients are often affected by joint problems it also provides clear guidance on the surgical treatment of musculo-skeletal manifestations. The first part is devoted to the disease’s pathophysiology (differentiating hemophilia A and B), genetics, pharmacotherapy – including replacement and non-replacement therapy – and gene therapy, as well as quality of life issues – also related to hemophilia carriers. The second part is then focused on joint problems, ranging from joint health assessment and pain control to surgical treatment of acute hemarthrosis and hemophilic arthropathy, i.e. radiosynovectomy, total joint arthroplasty and arthroscopic joint debridement. Written by experts drawn from leading institutions involved in treatment of hemophilia and related joint problems, this book offers a valuable resource to hematologists, orthopedic surgeons, rehabilitation physicians, radiologists, and pharmacy researchers.
650		0	_aHematology.
650		0	_aOrthopedic surgery.
650		0	_aPhysical therapy.
650	1	4	_aHematology.
650	2	4	_aSurgical Orthopedics.
650	2	4	_aPhysiotherapy.
700	1		_aRodríguez-Merchán, E. Carlos. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
856	4	0	_uhttps://doi.org/10.1007/978-3-030-93990-8 _3Springer eBooks _zOnline access link to the resource
942			_2NLM _cEBK
041			_aeng